PLT Test Blog

Stockholm, Sweden When most people think of Sweden, they probably think of Volvo cars, now actually Chinese, and Ikea.   Today you will have to add keeping detailed centralized medical records to the list. Today’s study included 142,691 individuals from the entire population of Sweden with a diagnosis of bipolar disorder (BPD), schizophrenia (SCZ), or nonaffective psychosis (NAP) who were 15 years or older and who were treated with psychiatric medication from October 1, 2005, through December 31, 2016.   It is relevant to readers of this blog because it shows that some of the same cheap generic drugs written about in this blog to modify aspects of autistic brain function do indeed show up as beneficial to those Swedes, with BPP, SCZ or NAP, who had by chance been prescribed those drugs for other reasons. Numerous genetic studies have shown that the genes miss-expressed in autism overlap with those miss-expressed in bipolar (BPD) and schizophrenia (SCZ). Clearly some people wil...

Myelination in the Central Nervous System (CNS)                  Oligodendrocyte myelinating multiple axons The previous post on myelin was this one. Myelin and Skill Acquisition, Treating MS, plus Tuning P2X7 In that post we saw that you can activate P2X7 receptors with an antihistamine called Clemastine and you can block P2X7 with another cheap antihistamine called Oxatomide. The P2X7 receptor plays a role in both inflammation and myelination and this receptor appears to be linked to neurological disorders including schizophrenia and even depression. In that post I also compared experimental MS therapies with experimental autism therapies. The yellow box means, we know it works, at least for some people, based on trial results. The widely available PDE4 inhibitor, Roflumilast, has been patented as a cognitive enhancer, but even at that lower dose it can make people vomit.   Ibudilast seems to have fewer side effects and is under inves...

The potential benefit of the ketone BHB in autism was covered extensively in earlier posts.   It looks like different people may benefit for entirely different reasons and some may not benefit at all.  Some MCT oils, taken as precursors to BHB, can actually make people worse. Measuring ketones and glucose in blood Click for a summary of the previous posts. Ketone Therapy in Autism (Summary of Parts 1-6) I know that some readers of this blog have found that BHB/C8 does indeed provide a benefit in their specific type of autism.   The benefit seems to vary, but given all the biological modes of action of the ketone BHB that is not surprising.   Increased speech is a frequently noted benefit. My initial combination of Ketoforce plus C8 continues to be effective. Substituting a cheaper MCT oil containing both C8 and C10 (Bulletproof XCT oil), was less effective and after a matter of weeks produced a negative effect. It appears that C10, after a while, can produce mild anx...

Today’s post is only marginally related to autism, but does again show how some common food products have potential medical benefits. Where I currently live people have been using apple cider vinegar (ACV) as a home remedy for generations. It is the apple part, rather than the vinegar part that is most interesting. I think they should continue with this home remedy, just be careful not to dissolve the enamel on their teeth.  Rather surprisingly we can link ACV to improving Bumetanide effectiveness in autism and the chemoprotective effect of statins. I have read so much research about statins, I do take Atorvastatin myself. The only downside is that research shows it does increase fasting glucose levels by about 0.4 mmol/L, exactly why nobody is quite sure. If you want to further boost the chemoprotective power of statins it seems you may need a little help from something called Phloretin. Phloretin is a phenol that occurs in apples and the leaves of apple trees.   Apple cider...