Autism & Schizophrenia - Histamine degradation via HMT (requiring SAMe) and via DAO
Today’s post is a little complicated because it links together various issues ranging from food allergies to severe headaches, brain inflammation to arthritis. The common link here is histamine, which has been covered at length on this blog. You may recall that the H1 histamine receptor is the one associated with hay fever, H2 is expressed in the intestines and is involved in regulating acidity levels, H3 is mainly found in the central nervous system (CNS). The Histamine H4 receptor has been shown to be involved in mediating eosinophil shape change and mast cell chemotaxis . Here is the full paper, for those interested in mast cells:- Histamine H4 Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells In addition to all these receptors, histamine causes an increase in the pro-inflammatory cytokine IL-6. IL-6 is elevated in autism and many other inflammatory conditions ranging from arthritis to traumatic brain injury (TBI). One of interesting inte...