PLT Test Blog

Dr Frye is embarking on a multi-million dollar trial of Calcium Folinate (Leucovorin) to improve speech in autism.   I just completed my much humbler trial of a cheap generic Calcium Folinate. I determined it was far cheaper and simpler to make a trial, than arrange for the blood test.   The other reason is that I note in the US they are prescribing Leucovorin, even if you test negative in the test for autoantibodies. http://iliadneuro.com/order-a-kit.html Dr Frye thinks many people with autism have low levels of folate inside their brain due to antibodies blocking folate crossing the blood brain barrier.   He even suggests that perhaps the source of these antibodies is your gut and they are produced as a reaction to cow’s milk. I wondered why speech would be so directly affected by folate, but speech is something that is very noticeable and measurable. I used 30mg of calcium folinate at breakfast and 15mg in the evening. After a few days there was very clearly more speec...

US-Russia cooperation has long been possible in Space, but not so often in Medicine.  NASA reportedly pays Russia $85 million per astronaut to go the International Space Station (ISS).   The US Space Shuttle program ended in 2011, leaving a Russian Soyuz rocket the only way to the ISS. This post comes ahead of the dietary autism post, awaited by Tanya.  It really is just a brief follow-on from the previous post. I have only just come across Anavex, which does add weight to the first post on sigma-1R.                                                                                                                 Hundreds of millions of dollars are being spent in the US to develop a safe sigma-1R ago...

The mechanism controlling transporting just the “right” number of GABA A receptors Today’s post is not for the faint-hearted.   It is another one that could just keep on rolling.   Ling will like it. It again shows that GABA A receptors are at the centre of much autism, whether single gene or idiopathic. Today we highlight what can go wrong as these receptors are “transported”. Today’s post also draws on several quite recent papers. It seeks to tie together some previous things mentioned in this blog like the symptoms of pain, particularly felt in the head, sensory sensitivity with dysfunction processes like autophagy and linking it all back to the GABA A  receptor.  There is even a link at the end to the "fever effect", which occurs when a high temperature in some people causes a marked improvement in their autism symptoms. We will come across some expensive drugs like Erenumab, the medical food PEA ( Palmitoylethanolamide) and indeed Natasa’s favourite, CBD ( Can...