Connecting Estradiol with WNK, SPAK and OSR1; plus Taurine
Japan, home to today’s complicated research Today’s post hopes to give a more complete picture of the various processes involved in shifting the immature neurons often found in autism towards the mature neurons, found in most people. This stalled process is complex and may only apply to around half of all autism. The post assumes prior knowledge from previous posts about the GABA switch and the KCC2 and NKCC1 chloride cotransporters. The best graphic I found is below and includes almost everything. The paper itself is very thorough and I recommend the scientists among you read the paper rather than my post. What we want to understand is why neurons did not switch from immature to mature, in the process I am calling the “GABA switch”. We know a great deal about what happens before and after the switch and many processes that can be involved, but the exact switch itself remains undefined. In a previous post I highlighted that neuroligin 2 (NL2)/RORa may be the GABA sw...