PLT Test Blog

The common form of Leucovorin Calcium is for injection, but it exists in  tablet form.  Maybe another opportunity for intra-nasal delivery? As pointed out by Tyler, Richard Frye has published his trial on the effect of mega-dose folinic acid in children with autism and language impairment. FRAA (folate receptor- α autoantibody) status was predictive of response to treatment.  This means that people who are FRAA positive are likely to really benefit from folinic acid treatment. There are different types of folinic acid .  Dr Frye uses Calcium Leucovorin ( Calcium Folinate ) , which is used in chemotherapy.  It is given by intramuscular injection or orally. Dr Frye uses the oral form. Folinic acid should be distinguished from   folic acid   (vitamin B 9 ). However, folinic acid is a   vitamer   for folic acid, and has the full vitamin activity of this vitamin. The dose is huge by normal standards of vitamin B 9 .  It was 2   mg/   kg ...

  China, where things tend to be big, even their clinical trials A short while ago we looked at the possible mechanisms behind a reader’s successful experience in use of Mirtazapine (Remeron) in autism, then being prescribed to increase appetite. Mirtazapine is a tricyclic antidepressant, meaning it is very closely related to first generation antihistamines, but it has numerous other effects;  more of that later. Folate is vitamin B9.  Folic acid is synthetically produced, and used in   fortified foods   and   supplements   on the theory that it is converted into folate, which may not be the case. It appears that in both schizophrenia and autism there is a family of possible folate dysfunctions that range from minor to severe.  The mild dysfunction responds to a small supplement of folate, while the severe dysfunction requires a much larger supplement of folate. Roger, another reader of this blog has the more severe dysfunction called Cerebral Fol...