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Showing posts with the label mitochondria

Leaky ATP from either Mitochondria or Neurons in Fragile X and Autism

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    For leaky ATP, Popeye might want to try Dexpramipexole and Suramin, or even the already approved Mirapex If you are old enough to be a parent, you will have encountered problems with some kind of leak.  A leaky roof, a leaky pipe, a leaky washing machine, an air-conditioning unit... The list goes on, the older you get. I have been preoccupied by fixing a leak recently.   We have a large roof terrace and, in the winter, water started leaking from the ceiling in the floor below.   I improvised a system to catch all the water, but still I had to find the source of the leak. I did finally find the source of the problem and most importantly without digging up 95% of the terrace.   Now I have to put the 5% back together again. Leaks are often extremely difficult to locate, because water always finds the easiest path and the dripping you see might have originated from a leak far away.   Nobody wants to fix leaks, because it can be a pretty thankle...

Lethargy and Autism

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  That alternative world, where you fix things when they are not working I do sometimes forget the world that most people live in, when it comes to (not) understanding and (not) treating autism. I decided to write this post on lethargy and autism, after being prompted by a friend who contacted me and told me that his son with autism is very lethargic (physically and mentally). I replied with the suggestion that he try a little scoop of Agmatine Sulphate.   Now his son is able to go for long walks, without constantly wanting to stop for a rest.   The Dad asked me to share his positive experience with Agmatine. A few years ago, this boy was diagnosed by Dr Kelley with mitochondrial dysfunction.   People with mitochondrial dysfunction should indeed have poor exercise endurance, this is because they lack the enzymes needed in a process called oxidative phosphorylation (OXPHOS).   OXPHOS is the metabolic pathway in which cells use enzymes to oxidize nutrients, ther...

Sulfarlem / Anethole trithione (AOL) for Autism secondary to Mitochondrial Dysfunction (AMD)? Not to mention Metastasis

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Sulfarlem has been used to treat dry mouths for half a century By www.scientificanimations.com - http://www.scientificanimations.com/wiki-images/, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=77499374 Sulfarlem is a drug containing a chemical called Anethole trithione . Anethole is an organic compound used as a flavouring, i t contributes a large component of the odour and flavour of anise and fennel. Anise seed, or aniseed, contains a large amount of Anethole. The popular Greek drink Ouzo turns cloudy when diluted with water because of the Anethole. For the French it is called Pastis.                                                                  ...