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Showing posts with the label NAD

The Kynurenine Pathway in Autism and its modification using Sulforaphane or the probiotic Lactobacillus Plantarum 299v

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    A pathway to somewhere, hopefully Today’s post was prompted by our reader George’s observation that the probiotic Lactobacillus Plantarum 299v increased speech in his adult son.   This widely available probiotic is commonly used to treat IBS (Irritable Bowel Syndrome) and I did mention it in a recent post about Eubiotics. Eubiotics for GI Dysfunction and some Autism Increased speech is a target for many people treating autism and this probiotic is known to be safely used long term - so it is interesting. Since I already had this probiotic at home, I made a trial and I observed a very similar effect to what happened several years ago when Monty started to use Sulforaphane / broccoli sprout powder.   The effect of broccoli powder was a brief period of euphoria about 20 minutes later and a then a marked increase in verbalization.   The effect on mood was seen by some other readers, but not the majority. I recall back then a very happy parent who was feedin...

How to increase Oxytocin (OT) effects in the autistic brain? OT nasal spray, L. reuteri DSM 17938, Magnesium, Estradiol, Nicotinamide riboside …

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  Struggle to make friends? Consider Oxytocin Today’s post was going to be about FMT super-donors, but instead we have a post about new insights into using oxytocin to treat autism.   From personal experience I can say that you really can target oxytocin receptors to affect mood/behavior; I have no personal experience of FMT (fecal microbiota transplants), but thousands of people use it for many conditions.   The FMT post will be next. Oxytocin and vasopressin are two hormones, made in the hypothalamus, that are established targets for autism treatment . They are released into the bloodstream where they carry out their best-known functions, but they are also released from the hypothalamus directly into the brain where these hormones have entirely different functions. Both oxytocin and vasopressin can be given as nasal sprays to enter the central nervous system (CNS) rather than just the blood stream.   This means you get the brain effects of the hormone, also known ...