PLT Test Blog

   Warsaw University of Life Sciences, Source: Wikipedia Regular readers of this blog will have noticed there are some strange things going on related to endocrinology in the autistic brain; in effect there are low levels of certain critical hormones. We saw in research from the Harvard Medical School that it seemed that oxidative stress in the brain affected the level of a key enzyme D2 ( iodothyronine deiodinase type 2).   D2 has an important role; it converts the passive thyroid pro-hormone T4,   into the active thyroid hormone T3.   Without enough T3, you are said to be hypothyroid.   When the brain is affected, it is called central hypothyroidism. As T3 is essential for cellular metabolism, growth and differentiation, and thus critical for brain development, thyroid deficiency during embryonic or early postnatal periods would likely lead to developmental abnormalities, including autism. Now we have some follow up research from Harvard and Warsaw Univ...

This is a repost  from last year - the original got deleted.  TRH is another area that you will not find much if you Google "autism plus ......".  But, since writing this post, I did find other people using it for various neurological conditions.  It is another hormone/drug that seems to have a good effect when used in very small doses. Abstract Based on observation of a single boy with autism, thorough desk research, and one simple experiment, it is hypothesized that the hormone TRH (thyrotropin-releasing hormone) can induce a brief period of behavioural homeostatis.   During this period, behaviours appear to be modified to near normal.   It is further hypothesized that a TRH analog, Taltirelin, could induce prolonged periods of behavioural homeostatis . Due to the very short half-life of TRH in plasma, it is necessary to use an analog of TRH.   The proposed TRH analog is Taltirelin hydrate, already licensed for human use since 2000 in Japan...