Statins for Neuroprotection in Autism - Part 2
I suggest you start by reading Part 1. Click here for Part 1 Choice of Statin Some statins are soluble in fats/lipids (lipophilic) and some are more soluble in water. In order to cross the blood brain barrier (BBB) to reach the cerebellum and the Purkinje Cell Layer (PCL) a lipophilic statin will be required. There is a choice of three: - atorvastatin, lovastatin, and simvastatin. These are also among the most commonly prescribed for cholesterol reduction and so are widely available and inexpensive. I chose atorvastatin. Some statins are derived from fungi, but atorvastatin is synthetic. Lovastatin and simvastatin are pro-drugs, whereas atorvastatin is already in an active form straight out of the box. Absorption of atorvastatin decreases when taken with food. Due to its long half-life, atorvastatin can be administered at any time of day. Atorvastatin is approved for use in children as young as 10 and in the US is prescribed to chil...