Regulation of the Arachidonic Acid (AA) Cascade to treat Inflammatory Disease via aspirin, diet, lithium or better still calcium channels
A rather simpler type of cascade Today’s post was really to explain why for some people with autism their GI problems disappear when they take the calcium channel blocker verapamil. Along the way, we will see that a similar mechanism is behind the effectiveness of both low dose aspirin and even high doses of omega 3 oil, when combined with lower dietary intake of omega 6. There have been several studies regarding omega 3 oil in autism, but overall they are not very conclusive. A small number of people with autism and ADHD seem to benefit. Low dose aspirin is now very commonly prescribed to people at risk of a heart attack. In essence you can say that too much of the omega-6 fatty acid arachidonic acid (AA) is potentially bad for you; it allows for the body to become inflamed, but more important seems to be the AA cascade which determines whether the AA is converted to prostaglandins or leukotrienes. Fortunately prostaglandins and leukotrienes tend to act ...