PLT Test Blog

I started to write this post a long time ago, when Agnieszka first highlighted an interview with Dr Hagerman from UC Davis.  Hagerman is experimenting in using Metformin to treat Fragile-X. Having again be reminded about Metformin, I realized that I never finished my post on this subject. With some extras about autophagy and a nice graphic courtesy of Ling’s excellent paper, here it is.   Metformin has already been covered in 5 previous posts. https://epiphanyasd.blogspot.com/search/label/metformin One interesting point is that the researchers at UC Davis are using the measurement of IQ as one of the outcome measures in their trial of Metformin.   I have been suggesting the French Bumetanide researchers do this for a long time. It is my opinion that simple medical interventions can have a profound impact on the IQ of some people with severe autism. I mean raising IQ not by 5-10 points as at UC Davis, but by 20-50 points.   IQ can be measured using standardized tools ...

The mechanism controlling transporting just the “right” number of GABA A receptors Today’s post is not for the faint-hearted.   It is another one that could just keep on rolling.   Ling will like it. It again shows that GABA A receptors are at the centre of much autism, whether single gene or idiopathic. Today we highlight what can go wrong as these receptors are “transported”. Today’s post also draws on several quite recent papers. It seeks to tie together some previous things mentioned in this blog like the symptoms of pain, particularly felt in the head, sensory sensitivity with dysfunction processes like autophagy and linking it all back to the GABA A  receptor.  There is even a link at the end to the "fever effect", which occurs when a high temperature in some people causes a marked improvement in their autism symptoms. We will come across some expensive drugs like Erenumab, the medical food PEA ( Palmitoylethanolamide) and indeed Natasa’s favourite, CBD ( Can...