PLT Test Blog

When I first connected histamine to autism, I did not realize that this might be a common problem.   The most frequently viewed post on this blog is one on histamine and autism; so at least 10,000 people out there have googled “autism and histamine”. Two years later, the therapy is still evolving and it should be said that, what works best for one person may not help in another person.  The main point is that in some people with autism, they face a summertime regression due to the effect of allergy.  So bad behaviours and aggression increase and good behaviours and indeed cognitive function decrease.  This appears to be the result of histamine and a pro-inflammatory cytokine called IL-6. For the 2015 pollen season, which started early where we live, this is what we are using:- Azelastine nasal spray, this is an H1 antihistamine that is also inhibits mast cells from “degranulating” and emptying their load of pro-inflammatory substances.  Once a day. Quercetin i...

I wrote earlier posts about the role of histamine in summertime autism flare-ups.   I ended up using a combination of a regular antihistamine like Claritin with Ketotifen, which though also an antihistamine, is a partial mast cell stabilizer .   I recently found a very useful table which shows different regimens that can be used for just this problem:-   The table is from a paper, again by Dr Theoharides, called:   Autism: an emerging ‘neuroimmune disorder’ in search   of therapy Rupatadine is a safe and cheap antihistamine mainly sold in Europe.   The science appears to show that it is more effective at stabilizing the mast cells involved in allergies than Ketotifen . The problem I found with Ketotifen is that it has very little immediate effect, unlike Claritin, so I ended up using both.   By the looks of things, Rupatadine may indeed do the job of both. The table also mentions Periactin , which is an old first generati...