PLT Test Blog

  Our reader in Canada, AJ, did highlight a case series from Norway that showed that high dose Betaine/TMG was effective in improving functioning in people with autism due to creatine transporter deficiency.   The use of Betaine/TMG was really just stumbled upon and the authors considered what the beneficial possible mode of action could be.   Betaine (TMG) and Gene Therapy as potential alternatives to Bumetanide Treatment in Autism?   The effect was only present at high dose (7-10 g a day) not the much lower dose used by some DAN/MAPS doctors, who do prescribe TMG and the closely related DMG. The paper suggested that one possible effect might have been lowering chloride levels within neurons.   This is also the effect of Bumetanide. AJ suggested that Betaine/TMG might be an alternative to Bumetanide and one that does not need a prescription. Our reader Nancy reported a benefit in her adult son. The question is not whether or not high dose TMG is a useful ...

  Nestle’s research centre in Lausanne, Switzerland I did write extensively about the potential to treat some autism using the ketone BHB (beta hydroxybutyrate). This can be achieved either by following a strict ketogenic diet or just by eating medical foods that contain/produce BHB. Some readers are now big consumers of BHB supplements and anyone taking BHB should be interested in today’s paper, that I assume was paid for by Nestlé. Nestlé make everything from baby milk formula to George Clooney’s Nespresso.   You may not be aware that they also have a business selling medical food; they have been looking at ketones to treat Alzheimer’s for some time.   This is quite similar to Mars developing Cocoa flavanols to improve heart and brain health. Most ketone supplements are sold to help you lose weight or boost athletic performance.   The military also uses ketones in survival rations.   We saw that you can increase the level of ketones in your body by supplementi...

Agnieszka's KetoForce and C8 are new additions, last time it was Tyler's Agmatine as additions to the  Full Polypill I recently updated my autism Polypill. It is now the fifth version, so it is becoming ever more personalized to one specific case of autism.   I added caprylic acid C8 and KetoForce Beta Hydroxybutyrate. The full Polypill version 5 is here:    https://epiphanyasd.blogspot.com/p/polypill-for-autism.html I do feel that I am getting near the final version. I already am pretty sure what is going to be added in the sixth version. There are one or two potentially clever ideas in this blog that I have not yet developed. After my first year of autism research my doctor mother thought the result was good enough to stop, but I persevered and some further improvement did come. She was supportive of the concept but rather surprised it was possible. I think I have now achieved most of what is possible, which took an additional five years. Having recently been revi...

Today’s post is mainly about some “home-research” that was sent to me by a company that sold me C8 oil (caprylic acid MCT oil). It is not peer-reviewed research, but it is a well thought out home experiment measuring the level of the ketone BHB in the blood of two healthy young adults testing a range of commercially available products. It is important to note that BHB was measured in blood and not urine, which is a big plus for the experiment. Dr D’Agostino’s starting dose First, a recap of where we started a few months ago in this blog. One of the leading ketone researchers is Dr D’Agostino and his suggested starting dose on ketone supplements is 10 ml of Ketoforce and 10ml of C8/caprylic acid. We saw in earlier posts that the amount of BHB produced by taking C8 is highly dependent on whether it is taken with food. Taken on an empty stomach resulted in more BHB in the bloodstream. 10 ml of KetoForce contains 4g of BHB along with 500mg of sodium and 500mg of potassium. BHB salts and BH...