PLT Test Blog

Breakfast overlooking the river Thames The more typical English Breakfast If you happen to stay at a very nice hotel in London, the best meal to have is breakfast and after that comes tea.   The other meals are unlikely to feature much memorable English food. Whether it is the five-star Savoy, overlooking the river Thames, or the Travelodge by the station, mushrooms will be on the menu.   The movers and shakers actually get up early and have their power meetings over breakfast at the Savoy. This is not so expensive and a good way to experience British cuisine, served in a much more spacious environment than most restaurants.   Scotland contributes its porridge and black pudding, kippers might be on offer, but there will be mushrooms, a regular part of even the humblest hotel’s English breakfast. Mushrooms may 'reduce the risk of mild brain decline'   Eating mushrooms more than twice a week could prevent memory and language problems occurring in the over-60s, researc...

Karimnagar, India, where Schizophrenic Rats respond well to Beetroot Juice If you are not old enough to be interested in dementia, skip through those parts of this post and read about schizophrenic mice and beetroot juice. There have been earlier posts regarding using nitric oxide (NO) to improve circulation and derive a cognitive benefit. Many sportsmen have followed up on the research studies that show exercise endurance is improved after taking beet root juice. Since it is not a banned substance they are free to benefit from it. We know that beet root does not only reduces blood pressure but it actually can increases perfusion, or blood flow, to the brain. Reduced blood flow to the brain is a feature of some dementia. Studies have used MRI to show that circulation is increased. A follow up study has recently been published which shows that beet root juice combined with exercise produced MRI results that resemble those of much younger adults. In a previous post we saw that cocoa flav...

Today’s post is about OAT3, highlighted by the green lines. The interventions reduce renal excretion and raise plasma concentration rather than directly improving transport across the BBB Today’s post is a collaboration. Our reader Ling pointed out research trying to boost the bioavailability of bumetanide using something clever called an OAT3 inhibitor.   This would reduce the rate at which the body excretes bumetanide and thus potentially improve its therapeutic effect. Petra, our reader from Greece, pointed out that in her son Bumetanide seemed to work better when taken with Greek coffee and that that Greek Grandpas like to take their diuretics with a steaming Greek coffee. Most people, me included, automatically think caffeine when someone mentions coffee. So I assumed that caffeine might be an OAT3 inhibitor and I did make some experiments on that basis. There is no research data to support caffeine as an OAT3 inhibitor. Recently I was again looking for other potential Bumetan...