Modulation of IP3 receptors in Autism – Pancreatitis and Caffeine?
This post stems from our Greek reader Petra's original observations about the combined effects of coffee and bumetanide. In earlier posts we learned that one likely nexus in autism is the IP3 receptor that releases calcium from a store within each cell. It turns out that too little/too much activity from IP3 receptors is a feature of a wide range of disease, some of which you may not have heard of, including:- · Gillespie syndrome, a genetic condition leading to MR/ID, ataxia and notably part of the iris to be missing · S pinocerebellar ataxias, genetic conditions that cause loss of movement control · Glioblastoma, an aggressive and “untreatable” brain cancer · Alzheimer’s disease · Huntington’s disease · Pancreatitis, inflammation of the pancreas where your body makes its digestive enzymes and insulin ...