PLT Test Blog

Azosemide  C 12 H 11 ClN 6 O 2 S 2    Source: https://pubchem.ncbi.nlm.nih.gov/compound/azosemide Today’s post may be of interest to those already using bumetanide for autism and for those considering doing so .  It does go into the details, because they really do matter and does assume some prior knowledge from earlier posts. There has been a very thorough new paper published by a group at Johns Hopkins:- Off-Label Use of Bumetanide for Brain Disorders: An Overview It does cover all the usual issues and raises some points that have not been covered yet in this blog.   One point is treating autism prenatally. This issue was studied twice in rats, and the recent study was sent to me by Dr Ben Ari.   Short term treatment during pregnancy produced a permanent benefit. Maternal bumetanide treatment prevents the overgrowth in the VPA condition              Brief maternal administration of bumetanide before birth restores low ...

I did think of highlighting this post to the Bumetanide researchers in France, but I do not think they would take it seriously. Another one to mention would be this new study, funded by Rodakis, to look at why some antibiotics improve some autism.   Dr Luna at Baylor College is running the study.   Its basic assumption is that the effect must be to do with bacteria, but as our reader Agnieszka has highlighted, common penicillin type antibiotics increase expression of the gene GLT-1 which then reduces glutamate in the brain.   It has nothing to do with bacteria.   Maybe for other antibiotics the effect does relate to bacteria. But if you tell Dr Luna about GLT-1, quite likely she will not be interested.    Study to investigate connection between antibiotic use and autism symptoms Researchers will compare the gut microbiome (bacteria, yeasts and fungi found in the gut) and metabolome (small biological molecules produced by the microbes) of those who experienc...