PLT Test Blog

  Will Betahistine provide a benefit? Today’s post is the logical follow on from the post showing that the new drug compound E-100 gives a benefit in two models of autism. Another Potential Autism Therapy - novel compound E100 from Krakow, a combined histamine H3 receptor blocker (H3R antagonist) and an acetylcholine esterase inhibitor (AChEI) We saw that E-100 has two modes of action, thought to be complementary:- ·         Acetylcholinesterase inhibitor (AChEI) ·         Histamine H3 antagonists (H3R antagonist) I think our reader Rene is thinking along the lines I suggested that you might achieve the same effects with existing generic drugs.   One combination would be Donepezil plus Betahistine. Donepezil has long been studied in autism, a recent example is here: Improvement of Language in Children with Autism with Combined Donepezil and Choline Treatment The safety and efficacy of a novel combinati...

  Super skinny is a poor role model and another driver of autism risk via ensuing endocrine problems While some types of autism cannot easily be prevented, those that relate to the lifestyle of future parents clearly can be reduced. Rather than just be shocked about an “autism epidemic”, with ever increasing prevalence, why not start doing something about it?  People are staying at home to reduce the incidence of Covid-19; the risk of autism can also be reduced. Today’s post is about the young females who, under peer pressure and Instagram pressure, choose to starve themselves in the pursuit of looking “good”. School lunches are a daily subject of conversation in our house, since I always ask Monty, now aged 16 with autism, what he had for lunch at school.   Monty’s assistant tells me that even though the lunches at school are not bad, he is one of the few to eat them all.   The boys generally just eat the meat and potatoes and do not touch the fruit, vegetables and ...