PLT Test Blog

    For leaky ATP, Popeye might want to try Dexpramipexole and Suramin, or even the already approved Mirapex If you are old enough to be a parent, you will have encountered problems with some kind of leak.  A leaky roof, a leaky pipe, a leaky washing machine, an air-conditioning unit... The list goes on, the older you get. I have been preoccupied by fixing a leak recently.   We have a large roof terrace and, in the winter, water started leaking from the ceiling in the floor below.   I improvised a system to catch all the water, but still I had to find the source of the leak. I did finally find the source of the problem and most importantly without digging up 95% of the terrace.   Now I have to put the 5% back together again. Leaks are often extremely difficult to locate, because water always finds the easiest path and the dripping you see might have originated from a leak far away.   Nobody wants to fix leaks, because it can be a pretty thankle...

BHI as a dynamic measure of the response of the body to stress In this scheme, healthy subjects have a high BHI with a high bioenergetic reserve capacity, high ATP-linked respiration (AL) and low proton leak (PL). The population of mitochondria is maintained by regenerative biogenesis. During normal metabolism, a sub-healthy mitochondrial population, still capable of meeting the energetic demand of the cell, accumulates functional defects, which can be repaired or turned over by mitophagy. Chronic metabolic stress induces damage in the mitochondrial respiratory machinery by progressively decreasing mitochondrial function and this manifests as low ATP-linked respiration, low reserve capacity and high non-mitochondrial (e.g. ROS generation) respiration. These bioenergetically inefficient damaged mitochondria exhibit increased proton leak and require higher levels of ATP for maintaining organelle integrity, which increases the basal oxygen consumption. In addition, chronic metabolic stre...

Today’s post was originally intended to look at some further methods used to enhance cognitive function. Unlike people with typical mild cognitive impairment (MCI), some people with autism exhibit highly variable cognitive function, one way this is visible is in their hand writing quality. We previously saw that in cases of PANDAS/PANS, deterioration of hand writing is also seen during acute episodes.   One possible cause of cognitive decline is mitochondrial dysfunction.   This is a highly complex subject in its own right and so I decided to start with a post introducing mitochondrial disease and dysfunction.     Mitochondria Mitochondria are tiny organelles found in almost every cell in the body. These organelles are responsible for creating 90% of cellular energy necessary to maintain life and support growth. Mitochondrial disease occurs when mitochondria in the cells fail to produce enough energy to sustain cell life. When enough cells cease to function properly ...