Pep up those Purkinje cells
In the previous post we established that both oxidative stress and neuroinflammation can be measured. We learned from the clever people at Johns Hopkins that the site of the greatest inflammation is in the cerebelleum; as they put it:- Based on our observations, selective processes of neuronal degeneration and neuroglial activation appear to occur predominantly in the Purkinje cell layer (PCL) and granular cell layer (GCL) areas of the cerebellum in autistic subjects. Now, you may recall that I recommended an excellent book called "Autism: Oxidative Stress, Inflammation and Immune Abnormalities". The book is from 2010, and since then the authors have been busy. In 2012 they published a study called: Brain Region-Specific Glutathione Redox Imbalance in Autism This study tells us which parts of the brain are most affected by oxidative stress. The abnormal level of GSH redox (the marker for oxidative stress) was highest in the cerebellum and ...