Polygenic Disorders that Overlap – Autism(s), Schizophrenia(s), Bipolar(s) and ADHD(s) – Creativity & Intelligence
Blogs are inevitably rather jumbled up and lack a clear structure; today’s post really should be at the beginning. One clear message from the more sophisticated research into neuropsychiatric disorders is that they are generally associated with variances in the expression of numerous different genes, making them polygenic. What I find interesting is that there is a substantial overlap in the genes that are miss-expressed across different neuropsychiatric disorders. This is further proof, if it was needed, that the observational diagnoses used by psychiatrists are rather primitive. So individual people will have a near unique set of genetic variances that make their symptoms slightly different to everyone else. However it is highly likely that discrete biological dysfunctions will exist across the diagnoses. So for example elevated intracellular chloride will be found in some autism and some schizophrenia. A calcium channelopathy affecting Cav1.2 would be found in so...