PLT Test Blog

  Adult-sized people with autism can cause property damage and much worse. I am told that summertime raging is a common problem encountered by neurologists, but it remains poorly understood and usually remains untreated. The most common worry for parents of toddlers diagnosed with severe autism is their lack of speech. By the time these children reach adulthood, the biggest worry for parents is often aggression and self-injury. Often it is the mother who faces the worst episodes of aggression, which is a really cruel turn of events. Aggression is usually not present in young children with autism, in some people it never develops, but in others it later becomes established as a learned behavior and then you are stuck with how to deal with it. One of my own therapy targets has long been to improve cognitive function; this can indeed be achieved and then you can improve important daily living skills (adaptive function). Some steps that you can take to improve cognition, and indee...

By far the most read post in this blog is one about histamine and allergies, which means many people are searching on Google for “histamine, allergy and autism”. Our reader Kei recently commented that his daughter, without allergy, was again showing signs of summertime raging and that his neurologist confirmed that summertime raging does indeed happen and nobody knows why. I did figure out how to deal with our version of “summertime raging” and the post-bumetanide “dumber in the summer” phenomena.   There were several posts on this subject.   The lasting solution was to treat the raging as if it was caused by inflammation driven by pollen allergy and to note that inflammation will further worsen the KCC2/NKCC1 imbalance in Bumetanide-responsive autism, making those people appear “dumber in the summer”.   This also accounts for the “Bumetanide has stopped working” phenomenon, reported by some parents.   You need to minimize inflammation from allergy and increase Bumet...

  Repurposing what already exists – cheap, safe, effective and sometimes colourful Today’s post is nice and simple. Yet another sub-type of autism is shown in a clinical trial to respond to the cheap drug bumetanide, this time it is children diagnosed with TSC ( tuberous sclerosis complex); TSC is a leading genetic cause of autism often used in research. In France researchers repurposed Folinoral, a lower dose equivalent of Dr Frye’s, and our reader Roger’s, Leucovorin to treat autism with a positive result.  Folinoral is Calcium Folinate, but the dose was just 5mg twice a day, much less than the dose used in the US research. The potential off-label uses for Verapamil, the old calcium channel blocker helpful in some autism, continue to grow. Original purpose:   Lower blood pressure by blocking L-type calcium channels Alternative uses: ·         Treating bipolar disorder ·         Treating cluster h...

I started to write this post a long time ago, when Agnieszka first highlighted an interview with Dr Hagerman from UC Davis.  Hagerman is experimenting in using Metformin to treat Fragile-X. Having again be reminded about Metformin, I realized that I never finished my post on this subject. With some extras about autophagy and a nice graphic courtesy of Ling’s excellent paper, here it is.   Metformin has already been covered in 5 previous posts. https://epiphanyasd.blogspot.com/search/label/metformin One interesting point is that the researchers at UC Davis are using the measurement of IQ as one of the outcome measures in their trial of Metformin.   I have been suggesting the French Bumetanide researchers do this for a long time. It is my opinion that simple medical interventions can have a profound impact on the IQ of some people with severe autism. I mean raising IQ not by 5-10 points as at UC Davis, but by 20-50 points.   IQ can be measured using standardized tools ...