PLT Test Blog

  Our reader in Canada, AJ, did highlight a case series from Norway that showed that high dose Betaine/TMG was effective in improving functioning in people with autism due to creatine transporter deficiency.   The use of Betaine/TMG was really just stumbled upon and the authors considered what the beneficial possible mode of action could be.   Betaine (TMG) and Gene Therapy as potential alternatives to Bumetanide Treatment in Autism?   The effect was only present at high dose (7-10 g a day) not the much lower dose used by some DAN/MAPS doctors, who do prescribe TMG and the closely related DMG. The paper suggested that one possible effect might have been lowering chloride levels within neurons.   This is also the effect of Bumetanide. AJ suggested that Betaine/TMG might be an alternative to Bumetanide and one that does not need a prescription. Our reader Nancy reported a benefit in her adult son. The question is not whether or not high dose TMG is a useful ...

  Some readers of this blog are interested in the potential of mefenamic acid (MFA), sold as Ponstan, to treat autism. There is a lack of evidence currently.   On the other hand, the evidence looks pretty overwhelming in the case of this class of drug to treat Alzheimer’s, hence today’s post. If you have a case of epilepsy at home, you can follow up on that loose end I left. I also introduce MFA as a therapy for sound sensitivity and Misophonia. It was pretty impressive in the case of Monty, aged 18 with ASD.   The highlights are:   ·         Fenamate NSAIDs reduce the incidence of Alzheimer’s ·         Fenamate NSAIDs delay the progression of those already with Alzheimer’s ·         Acetaminophen /Paracetamol worsens the progression of Alzheimer’s ·         Low dose aspirin is chemoprotective, as well as reducing blood ...