Another Potential Autism Therapy - novel compound E100 from Krakow, a combined histamine H3 receptor blocker (H3R antagonist) and an acetylcholine esterase inhibitor (AChEI)
Source: Sukiennice and Main Square as seen from St. Mary's Basilica Krakow’s old town is well worth a visit and is notable in Poland for not having been destroyed by the Germans, Russians or the US/UK during World War 2 Brain histamine and acetylcholine are implicated in cognitive disorders such as Alzheimer’s, schizophrenia, anxiety, and narcolepsy, all of which are found to be comorbid with autism. This led a group in the United Arab Emirates (UAE) to test a new compound developed in Krakow, Poland, to see if this new Alzheimer’s compound is effective in two different models of autism. The Valproic Acid induced model of autism and the BTBR models were chosen. The BTBR model is seen as a proxy for idiopathic autism; in this model there is no corpus callosum, which joins the left are right sides of the brain (red part in the graphic below). In an earlier post we looked at agenesis of the corpus callosum, which can be full or partial and is a f...