PLT Test Blog

“Pharmacokinetics” of a typical drug Today’s post is about what should be the optimal anti-oxidant therapy for autism, schizophrenia, COPD and any other disease in which oxidative stress is present.  You will have to be able to swallow pills, to fully benefit. NAC seems to be the most potent, safe, anti-oxidant, the only drawbacks are:- ·         Short half-life ·         Can taste/smell bad In autism, NAC is normally given three times a day, but often it is not practical to give a drug at precise intervals throughout the day. This is a common problem with many drugs and has been solved long ago – with the sustained release pill. If you find that four hours after giving NAC there is an increase in irritability, anxiety or stimming, it may be that oxidative stress has already returned.  It may be that other factors have triggered a higher load of oxidative stress.  The way to be sure is just to give a sm...

One of the post popular subjects on this blog is the use of NAC (N-acetyl cysteine) for autism. There are numerous earlier posts explaining how and why it works. Just look up NAC in the index by subject ; there are 19 posts, for those with plenty of time. (the labels function just gives the recent posts) NAC was shown in a clinical trial at Stanford to be an effective treatment for autism.  You might have expected that this would be quickly followed by further research, but since NAC is widely available as a cheap supplement, there is not much financial incentive for further research.  Without that research, mainstream doctors will never prescribe it. Beginner's guide to NAC  Highly respected researchers have shown that in many types of autism, oxidative stress is present and considered that NAC might be an effective therapy. In the past, some DAN-type doctors have used NAC, but the Stanford trial was the first mainstream trial for autism. For oxidative stress in asthma ...

Several people have mentioned to me a supplement called L-Carnosine, so I thought it was worthy of its own post. The first thing to note is lots of supplements have very similar names and indeed two entirely different substances are abbreviated to NAC. ·         Carnosine ·         Carnitine ·         L-Carnosine ·         L-Carnitine ·         N-Acetylcysteine    ( abbreviated to “NAC”) ·         N-Acetylcarnosine  (also abbreviated to “NAC”) In this blog, and in most literature on autism, NAC refers to N-Acetylcysteine. This post is about Carnosine and L-Carnosine, but there is also research on the use of Carnitine and L-Carnitine regarding autism and Retts syndrome.  So double check what is on the label, if you do indeed order some. Vladimir Gulevich...

In earlier posts we learned about two kinds of stress:- Oxidative stress is a biological stress that is measurable (GSH redox) and has been shown to be present in most autistic people. Psychological stress is a feeling we experience in difficult situations and is measurable by sampling the level of the hormone cortisol in saliva. It would appear that both types of stress are interrelated. We have already established that oxidative stress in autism can be successfully be treated with NAC.   NAC acts both as an anti-oxidant in its own right and as a precursor chemical to form GSH, the body’s own antioxidant.   NAC is cheap and widely available. The scientific literature regarding autism includes many references to inflammation of the brain, or neuroinflammation. It turns out that this inflammation is also measurable.   When samples of cerebrospinal fluid (CSF) are taken, elevated levels of chemicals called cytokines are found.   Certain cytokines are markers for neur...