PLT Test Blog

Sytrinol (Tangeretin), sacrificial Gummy Bear and Gingerol Today’s post follows on from an earlier one that introduced the term RASopathy.  A RASopathy is a disease characterized by over-activation of the RAS protein. RASopathies are of interest because if you have one, you are highly likely to also have autism. RAS dysfunction is also present in many types of cancer and there are existing drugs to inhibit RAS signaling.  It has been claimed that:- "If RAS proves to be a key player in autism …  it might suggest new treatments for autism, as many cancer drugs inhibit RAS signaling." Regular readers of the Simons Foundation autism blog may have read the following: RAS pathway, a potentially unifying theory of autism     Cancer pathway connects autism to set of rare disorders If RAS proves to be a key player in autism, she says, it might suggest new treatments for autism, as many cancer drugs inhibit RAS signaling. RAS-based interventions My Polypill already has o...

Today’s post was driven by another attempt not to take a statin. Statins are among the world’s most prescribed, and yet most maligned, drugs.  Hundreds of millions of people take a statin drug every day to lower their cholesterol, but a small, vocal minority complain about muscle pains, memory loss and even type 2 diabetes. Since my Polypill is evidently a therapy, and not a cure, for autism, the odds are that it will be needed life-long.  Regardless of the apparent lack of side-effects, nobody should be taking drugs/supplements that are not really needed.  Atorvastatin (Lipitor/Sortis) is part of my Polypill for the type of autism affecting Monty, aged 11, with ASD. Every time I stop the statin part of my Polypill therapy, I end up starting it again after only a one day break.  I notice all sorts of little behavioral changes that I really do not want to see.    These changes involve loss of initiative, flexibility and motivation.  I really do not see...