PLT Test Blog

  Results from the PaxMedica trial of Suramin For me, Bumetanide for Autism is now ten-year-old news, for us it has been working since 2012; the next interesting drugs in the pipeline include Suramin and Leucovorin. It is extremely difficult to trial Suramin at home, or indeed anywhere, and this makes it ever more desirable to many parents. Leucovorin (calcium folinate) is easy to obtain; you can even buy liquid calcium folinate from iHerb.   You can find out pretty quickly if it produces a profound benefit on your child’s type of autism. I wish Dr Frye and Professor Ramaekers good luck with the phase 3 trial of Leucovorin.   It certainly works for our adult reader Roger, but not for my 18 year old son, Monty.   Our reader SB’s child recently joined the group of confirmed responders. After I started writing this post, the results came in of a large (250 children) trial of intranasal oxytocin.   This trial failed to show any benefit, over the placebo, in inc...

  The Lateral Septum, in green, turns the volume  up or down in aggression Today’s post started by me checking for anything new in the research about the hormone Vasopressin and autism. I was surprised by just how much research continues to be published on the subject – no smoke without fire, perhaps. We also get another insight into how aggressive raging develops in the brain; we even have a photo. A novel therapy for Fragile-X is also thrown into the mix, due to a link to oxytocin. So, what is cooking in the research? The first thing to note is that you really do have to look at both Oxytocin and Vasopressin, because these two hormones are very closely related. We have previously looked at the autism gene NLGN3, this gene encodes the cute sounding neuroligin-3.   https://epiphanyasd.blogspot.com/search/label/neuroglin   The reason people with Fragile-X have autism is because they lack the protein FMRP ( Fragile X mental retardation protein). In healthy n...

  There are two closely related hormones, vasopressin and oxytocin, that have been extensively researched in autism.   With oxytocin you can modify social-bonding behavior. You can increase oxytocin in the brain either via a nasal spray containing oxytocin, or you can add a specific bacterium to your gut that triggers a signal to the brain to produce more of its own oxytocin.   The latter is my preferred method, because you can produce a mild long-lasting effect throughout the day. Oxytocin has a very short life and it does not cross the blood brain barrier. There is even a new study in the works that will compare these two methods of treating autism.   Probiotics and oxytocin nasal spray as neuro-social-behavioral interventions for patients with autism spectrum disorders: a pilot randomized controlled trial protocol Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in social interaction and communication. Oxyt...