PLT Test Blog

CAPE ( caffeic acid phenethyl ester ) is a substance known to be an inhibitor of PAK1.   PAK1 has been shown at MIT to be implicated in various disorders including Fragile X and schizophrenia.   PAK1 inhibitors are also effective in research models of various cancers, including leukemia. There are currently no approved PAK1 inhibitor drugs, although several are in development. PAK1 is also implicated in Neurofibromatosis, and clinicians have researched various alternative PAK1 inhibiting substances.  The two most interesting ones that I have already written posts about are:- ·         Ivermectin , an old anti-parasite drug (also shown effective in  leukemia) ·         BIO 30 propolis, rich in CAPE Ivermectin is already used as an autism treatment by “alternative” doctors who think autism is caused by parasites.   We saw in a recent post that a study looking for parasites in people with autis...

Today’s post will hopefully not get too complicated. As has been mentioned in this blog, and also at leading institutions like MIT, it does seem possible to fine-tune certain receptors in the brain that have become dysfunctional in autism.  In the case of MIT they were “tuning” a receptor called mGluR5, which they suggested was either hypo or hyper, in other words too much or too little, depending on what the underlying disease variant was. This was done with something called an allosteric modulator, either a positive one called PAM, or a negative one called NAM. They found that a particular glumate receptor, called mGluR5 , was dysfunction in many autism-like conditions.  But the nature of the dysfunction varied, so different people would require different treatments to return the receptor performance back to normal (top dead center).   So it really becomes like tuning your car engine.  As I have progressed in my review of the literature it becomes clear that n...