The Hyperuricosuric Subtype of Autism, Uridine and Antipurinergic Therapy
A subtype of people with classic autism have uric acid excretion which is elevated (>2 Standard Deviations above the normal mean). According to the research these hyperuricosuric autistic individuals may comprise approximately 20% of the autistic population. There is nothing new in these findings and the research goes back 15 years. At that time nobody looked too deeply as why uric acid was elevated and the role of the purine metabolism in behaviour. Dr Naviaux at the University of California is the researcher who is developing antipurinergic therapy. I suspect his research is really at the root of what is going on and that high uric acid is just a consequence of an upstream metabolic dysfunction. In the meantime, is there any benefit of treating people with autism and hyperuricemia ? It does seem that in some people doing just that does produce tangible benefits and not just in autism; there was even a study in bipolar disorder. In bipolar, verapamil can also...