PLT Test Blog

Source: Epiphany ASD Blog Today’s post is very relevant to dementia, relevant to schizophrenia and diabetes and I believe some autism, including that of my son; agmatine is part of his Polypill therapy. Arginine is highly versatile amino acid and you need the arginine metabolism to be working correctly, particularly in your brain. Arginine is a widely available from diet and can be produced from citrulline and indirectly from glutamine; so you are unlikely to be deficient in arginine, except in your brain and particularly if you have Alzheimer’s. In Alzheimer’s it has been shown that the microglia in effect destroy arginine in the brain and this may play a role in what initiates the disease. Research has suggested that a deficiency in polyamines, another derivative of Arginine, is a feature of dementia. A deficiency of arginine in the brain will likely cause a deficiency of polyamines. Your body needs nitric oxide to maintain a healthy blood pressure and this requires arginine to foll...

After several months of testing Agmatine, including stopping and then re-starting, it is time to add it to my PolyPill . The idea to trial Agmatine came from our reader Tyler. It ticks all the boxes, it really does have a benefit; that benefit continues for at least several months. When you stop taking it, the benefit stops and when you restart you see the same benefit return. It is safe, inexpensive and widely available if you live anywhere outside the EU. Since it is relatively recent to the market as a supplement, it can no longer be sold in the EU until someone applies for it to be approved; long established supplements bypass this recent legislation. There were earlier posts evaluating why it might help some types of autism and now there even is one study on an animal model of autism.   Hypoperfusion in Autism Revisited   Nitric Oxide (NO), Arginase and Endothelial Dysfunction in Autism   Agmatine - a Magic Bullet inClinical Neuroscience?   Agmatine rescues auti...

Karimnagar, India, where Schizophrenic Rats respond well to Beetroot Juice If you are not old enough to be interested in dementia, skip through those parts of this post and read about schizophrenic mice and beetroot juice. There have been earlier posts regarding using nitric oxide (NO) to improve circulation and derive a cognitive benefit. Many sportsmen have followed up on the research studies that show exercise endurance is improved after taking beet root juice. Since it is not a banned substance they are free to benefit from it. We know that beet root does not only reduces blood pressure but it actually can increases perfusion, or blood flow, to the brain. Reduced blood flow to the brain is a feature of some dementia. Studies have used MRI to show that circulation is increased. A follow up study has recently been published which shows that beet root juice combined with exercise produced MRI results that resemble those of much younger adults. In a previous post we saw that cocoa flav...