Clinical Trial of Mega-dose Folinic Acid in Autism
The common form of Leucovorin Calcium is for injection, but it exists in tablet form. Maybe another opportunity for intra-nasal delivery? As pointed out by Tyler, Richard Frye has published his trial on the effect of mega-dose folinic acid in children with autism and language impairment. FRAA (folate receptor- α autoantibody) status was predictive of response to treatment. This means that people who are FRAA positive are likely to really benefit from folinic acid treatment. There are different types of folinic acid . Dr Frye uses Calcium Leucovorin ( Calcium Folinate ) , which is used in chemotherapy. It is given by intramuscular injection or orally. Dr Frye uses the oral form. Folinic acid should be distinguished from folic acid (vitamin B 9 ). However, folinic acid is a vitamer for folic acid, and has the full vitamin activity of this vitamin. The dose is huge by normal standards of vitamin B 9 . It was 2 mg/ kg ...