Ketamine, Memantine, D-Cycloserin, Magnesium, Fenobam and yet more as Glutamatergic Modulators in Autism (and Fragile X)
Much of this blog to date has been connected with aspects related to the neurotransmitter GABA. It did get rather complicated, but at least for me, it has been highly rewarding. I have identified treatable dysfunctions in Monty, aged 10 with ASD, using Bumetanide and now Clonazepam. It is also clear that a group of people with autism also benefit from treatment with R-baclofen, a potent GABA B receptor agonist. R-baclofen/Arbaclofen and Arbaclofen Placarbil are not commercially available. The commercially available drug Baclofen contains R-Baclofen and another substance that, in-effect, works to oppose it and so may be much less effective. Based on the successful results of this investigation into GABA-related interventions, it would therefore make sense to look in detail at Glutamate, the other neurotransmitter that appears to be dysfunctional in many types of autism. As with GABA dysfunctions, there are already are some existing treatments for glutamate dysfunct...