PLT Test Blog

  62 clinical trials with Psilocybin are registered Today’s post is about treating a wide range of conditions that share neuroinflammation in common, by targeting the serotonin receptor 5-HT 2A . Severely disabling cluster headaches, that were seen as untreatable, have been resolved by monthly micro dosing with psilocybin. Psilocybin is a naturally occurring prodrug compound produced by more than 200 species of fungus, including magic mushrooms. Psilocybin is quickly converted by the body into Psilocin.   Psilocin Binding Profile Target Affinity Species   K i  (nM)   SERT 3,801.0 Human   5-HT 1A 567.4 Human   5-HT 1B 219.6 Human   5-HT 1D 36.4 Human   5-HT 1E 52.2 Human   5-HT 2A 107.2 Human   5...

Even I thought this post was rather a long slog, but I kept finding more and more evidence to support the basic premise, so I covered all the genes that came up for completeness. I have been going on about the relevance of calcium channels in autism for years. I have also pointed out that while you can have severe autism for a single mutated gene, you can also “just” have a miss-expression of that same gene, without any error in the code in your DNA. You can have a little bit of that severe autism phenotype.  You can even have the opposite dysfunction, which would usually be over-expression of that gene.  Once you have miss-expression of a gene it will cause a cascade of other effects. This means that while you may not be able to correct the initial genetic dysfunction, you may well be able to treat what comes further down the cascade. I like to look for associations, so I skip quickly through the research papers, but take note when I see links to things like:-   · ...