Cinnamon (Cinnamaldehyde), Mast Cells (Allergy) & Autism
A reader of the previous post on cinnamon left a helpful comment highlighting research that suggests yet another reason why Cinnamon might be an effective treatment for some types of autism. Cinnamon extract inhibits degranulation and de novo synthesis of inflammatory mediators in mast cells Abstract BACKGROUND: Mast cells (MC) are main effector cells of allergic and other inflammatory reactions; however, only a few anti-MC agents are available for therapy. It has been reported that cinnamon extract (CE) attenuates allergic symptoms by affecting immune cells; however, its influence on MC was not studied so far. Here, we analyzed the effects of CE on human and rodent MC in vitro and in vivo. METHODS: Expression of MC-specific proteases was examined in vivo in duodenum of mice following oral administration of CE. Release of mediators and phosphorylation of signaling molecules were analyzed in vitro in human MC isolated from intestinal tissue (hiMC) or RBL-2H3 cells challenged with ...