PLT Test Blog

Stockholm in spring Hot on the heels of the last post that showed that regulatory T cells (Tregs) may indeed be a useful target to treat inflammation in autism, today’s post is about the particular short chained fatty acid (SCFA) that I have chosen to treat it. There are seven SCFAs:- Formic acid , Acetic acid , Propionic acid , Butyric acid , Isobutyric acid , Valeric acid , Isovaleric acid . Based on my homework, I have chosen Butyric Acid. Some of my posts do not lead to therapeutic interventions, but the posts on Treg and SCFA are going to lead to some good options, particularly for those with GI problems. As usual with effective interventions, there are multiple possible modes of action.  Since I have introduced epigenetics to this blog, I will also highlight a paper showing the epigenetic effects of Butyric Acid.  My real objective is to increase Tregs , as a means of shifting the balance between the proinflammatory IL-6 and the anti-inflammatory IL-10 . Monty, aged 1...

  T Rex - for what turned out to be rather a monster post If the title of this post already makes sense, you probably do not need to read it. It is about regulatory T cells (Tregs), which are an interesting way to treat what I have termed the over-activated immune system in autism.  The same ideas can be extended to other conditions related to mast cells, and also potentially Multiple Sclerosis (MS), Irritable bowel Disease (IBD) and even obesity. Take Home Summary For those more interested in what can be done, rather than why, here is the conclusion from this post:- There are at least four possible ways to increase the number of regulatory T cells (Tregs), which should reduce pro-inflammatory cytokines (particularly IL-6) and increase anti-inflammatory cytokines (like IL-10).   It should also reduce obesity, protect against diabetes and protect against organ damage in those already diabetic. The simplest method is to increase production of small-chain fatty acids, w...