Endothelial Dysfunction - Oxidative Stress, Inflammation and BH4
This post is rather out of sequence, but it draws together several different topics that I have been investigating and introduces another chemical often mentioned in autism research, BH4. The factor that links them all together is something called Endothelial Dysfunction. This blog has already established that oxidative stress and neuroinflammation are the key drivers behind autism. It has not been clear whether the oxidative stress causes the inflammation, vice versa, or perhaps they are self perpetuating. In my ongoing investigation into the autism comorbidities of asthma and high cholesterol (proxy for cardiovascular disease), I have come across some tantalising fact, such as:- Asthma research shows that cigarette smoking gives you oxidative stress and this continues even after stopping smoking. The oxidative stress reduces the effectiveness of asthma drugs. Oxidative stress is a key factor in cardiovascular disease. BH4 also known as Tetrahydrobiopterin , THB, trad...