Verapamil or Rezular (R-verapamil) for Irritable Bowel Syndrome (IBS)?
A nasty condition that is equally nasty to spell - diarrhoea / diarrhea Today’s post may help to explain why some people’s GI problems seem to vanish when they take Verapamil for their autism. Verapamil is usually prescribed as an L-type calcium channel blocker, to lower blood pressure. This type of ion channel is widely expressed in the brain, the heart and the pancreas. The pancreas is where your body makes those digestive enzymes. Mast cells that release histamine also contain L-type calcium channels. Verapamil blocks the L-type calcium channel Cav1.2, which in posts a few years ago I showed could be relevant for some types of autism. An extreme dysfunction of this ion channel leads to Timothy Syndrome, which is a single gene variant of autism with severe heart defects. There is now some more recently published research which I have highlighted below. L-type calcium channels as drug targets in CNS disorders L-type calcium channels are present in most electrically excitable ...