GABAa receptor trafficking, Migraine, Pain, Light Sensitivity, Autophagy, Jacobsen Syndrome, Angelman Syndrome, GABARAP, TRPV1, PX-RICS, CaMKII and CGRP ... Oh and the "fever effect"
The mechanism controlling transporting just the “right” number of GABA A receptors Today’s post is not for the faint-hearted. It is another one that could just keep on rolling. Ling will like it. It again shows that GABA A receptors are at the centre of much autism, whether single gene or idiopathic. Today we highlight what can go wrong as these receptors are “transported”. Today’s post also draws on several quite recent papers. It seeks to tie together some previous things mentioned in this blog like the symptoms of pain, particularly felt in the head, sensory sensitivity with dysfunction processes like autophagy and linking it all back to the GABA A receptor. There is even a link at the end to the "fever effect", which occurs when a high temperature in some people causes a marked improvement in their autism symptoms. We will come across some expensive drugs like Erenumab, the medical food PEA ( Palmitoylethanolamide) and indeed Natasa’s favourite, CBD ( Can...