High dose Betaine/TMG, Low Dose Ponstan, Galavit, Humira, HMB (β-hydroxy-β-methylbutyrate) and Cetirizine for Palilalia/Scripting
Our reader in Canada, AJ, did highlight a case series from Norway that showed that high dose Betaine/TMG was effective in improving functioning in people with autism due to creatine transporter deficiency. The use of Betaine/TMG was really just stumbled upon and the authors considered what the beneficial possible mode of action could be. Betaine (TMG) and Gene Therapy as potential alternatives to Bumetanide Treatment in Autism? The effect was only present at high dose (7-10 g a day) not the much lower dose used by some DAN/MAPS doctors, who do prescribe TMG and the closely related DMG. The paper suggested that one possible effect might have been lowering chloride levels within neurons. This is also the effect of Bumetanide. AJ suggested that Betaine/TMG might be an alternative to Bumetanide and one that does not need a prescription. Our reader Nancy reported a benefit in her adult son. The question is not whether or not high dose TMG is a useful ...