A Deep Dive into Closely Interacting Genes/Proteins that Account for Numerous Autism/Epilepsy Syndromes – (all Calcium or Sodium ion channels)
Even I thought this post was rather a long slog, but I kept finding more and more evidence to support the basic premise, so I covered all the genes that came up for completeness. I have been going on about the relevance of calcium channels in autism for years. I have also pointed out that while you can have severe autism for a single mutated gene, you can also “just” have a miss-expression of that same gene, without any error in the code in your DNA. You can have a little bit of that severe autism phenotype. You can even have the opposite dysfunction, which would usually be over-expression of that gene. Once you have miss-expression of a gene it will cause a cascade of other effects. This means that while you may not be able to correct the initial genetic dysfunction, you may well be able to treat what comes further down the cascade. I like to look for associations, so I skip quickly through the research papers, but take note when I see links to things like:- · ...