PLT Test Blog

  They also had Pentoxifylline for autism back in the 1970s – time for a revival?   Pentoxifylline and other more modern PDE inhibitors have been mentioned many times in this blog. https://epiphanyasd.blogspot.com/search/label/PDE4 https://epiphanyasd.blogspot.com/search/label/Pentoxifylline Pentoxifylline has been used in autism clinical trials dating back almost 50 years. A casual observer would naturally assume it cannot possibly be effective, or else surely its use would have caught on by now. Some readers have long been using a PDE inhibitor as part of their child’s autism polytherapy. People have been asking me to let them know my thoughts on Pentoxifylline, the most accessible PDE inhibitor. I think the key is that we are talking about an add-on, or adjunct, therapy.   We are no longer talking about pentoxifylline therapy vs no therapy, as they were in the 1970s.   Even in those decades-old studies there was a sub group of “super responders”.   Either...

                                                 Clemastine is an old antihistamine drug that we saw in earlier posts can stimulate oligodendrocytes to work harder and produce more myelin. Myelin is needed to learn new skills and to control your body. It only starts to form in the third trimester, as the brain begins to grow rapidly. Myelination continues after birth but the rate appears to be controlled by social/emotional exposure.   The more isolated the baby is, the less myelin is produced.                            https://kids.frontiersin.org/article/10.3389/frym.2018.00020 Interruption of the myelination proces...

    A microglial cell, labelled in green, contacts and attacks a myelinated axon (in red). In the presence of the pHERV-W envelope protein, this interaction leads to axonal injury. The blue structures are cell nuclei. Credit: HHU / Joel Gruchot / Patrick Küry     It is surprising that only about 2% of human DNA encodes the 20,000 or so genes we all have.   The other 98% used to be called junk DNA. About 8% of your DNA is made up of Endogenous retroviruses (ERVs) that have been picked up during evolution and most of which have been inactivated and can indeed be regarded as junk. Some of these old viruses that became part of human DNA remain fully functional, can be activated; they are implicated in disease ranging from Multiple Sclerosis (MS), to cancer, to schizophrenia and ALS (motor neuron disease). The best documented ERV is the one that affects some people with MS, it is called HERV-W  (the H is for Human).   Only in the presence of a protein ...