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Showing posts with the label Vitamin A

2016 To-do List

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I expect many readers of this blog have a list of things to trial in 2016; I certainly do. Monty’s older brother, codenamed Ted, did say to me recently, “I thought you said you’d be all finished with this, in a couple of years”; that was indeed the intention.   A medicine cabinet to be proud of, but not mine It has now been three years.  I never really intended to go so deeply into the science, and I never expected there to be so many “obvious” things un/under-investigated by researchers. Most people diagnosed these days with “autism” are fortunate to be relatively mildly affected.  Parents of those kids likely find this blog rather shocking; how can so many pills be needed and still you want more? Some other people also diagnosed with autism, face really big challenges, not limited to:-          ·         Unable to talk ·         Unable to walk ·     ...

Vitamin A (and ATRA) Upregulate Oxytocin via CD38

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  A familiar site to Maja, the confluence of the Sava and the Danube Today’s post is to document an interesting discovery by Maja, one reader of this blog.  She is just ahead of some Korean researchers, who very recently published a paper in Experimental Neurobiology on the same subject. Maja noticed that giving a small dose of fish oil produced the same benefits as those often claimed for Oxytocin ; she then did some investigation and noted that an enzyme called CD38 upregulates oxytocin in the brain.  The level of CD38 is affected by inflammatory cytokines and certain vitamins.  In particular, all-trans retinoic acid (ATRA) increases CD38 . All-trans retinoic acid (ATRA) is made in the body from vitamin A.  ATRA is also called vitamin A acid. Maja suggested this paper:- All-trans Retinoic Acid Upregulates Reduced CD38 Transcription in Lymphoblastoid Cell Lines from Autism Spectrum Disorder Deficits in social behavior in mice lacking the CD38 gene have...