The GABA Switch, Altered GABAa Receptor subunit expression in Autism and Basmisanil
In today’s post I intended to dig a little deeper into the GABA switch, which appears to underlie much autism, schizophrenia, epilepsy, even Down Syndrome and, not to forget, many mood disorders. Once you start digging, it is rather hard to stop. There is literature on the subject, but very little (almost none, really) looks at the big picture of what is going on. It is the big picture that matters. The GABA switch(es); but how many are there? The post starts out relatively simple, but then it does get complicated, because I discovered a lot interesting avenues exist, that seem to have been completed ignored by autism research. It seems Down Syndrome researchers are better informed. So if you make it to the end of this post, you will have done well. It seems that there are tens, if not hundreds, of possible ways to repair the faulty GABA switches. It would very much become a case for personalized medicine, correcting the precise dysfunctions, withou...