PLT Test Blog

Asperger with his Little Professors This blog is focused more on severe autism, but today it is turn for the Aspies.   The post does rather ramble, because I included some old unused material on micro-dose LSD that may be Aspie-relevant. Most people diagnosed with autism these days do not have severe autism and so their ideal medical therapy may be very different to the Polypill, I developed for my son. For a young Aspie he might just need a single intervention like Sertraline (Zoloft) and nothing else, or perhaps Amantadine. There is more than twenty years of experience medically treating people with Asperger’s, but it very much remains a case of trial and error to find what works. It does look like most translational research in autism is now focused on those without problems with speech or cognition. That is good news for people with Asperger’s, not so good for the other end of the spectrum. The paper below is 20 years old, but the medical treatment has not become out of date. G...

Today’s post might seem to have a very complicated tittle, but to regular readers it is really just another take on what we have seen time and time again. Today we see how another steroid imbalance in autism – low levels of allopregnenolone in this case – affects the neurotransmitter GABA and indeed the chloride transporter KCC2. Putting Prozac/Zoloft to a better use? I did report previously on a trial in adults with autism where pregnenolone was used. Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. Pregnenolone - an effective OTC anti-inflammatory therapy for autism? Why Low Doses can work differently, or “Biphasic, U-shaped actions at the GABAa receptor” Recall that disturbed hormonal homeostasis is a key feature of autism. What matters is the level of each hormone inside the brain (i.e. centrally), not in your blood. The only way to get a reliable idea of what is going on would be to take a sample of spinal fluid. Today w...