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Showing posts with the label BBB

Autism Flare-Ups & Leaky Blood Brain Barrier

As I discussed in an earlier post, autism flare-ups occur regularly in the lives of many autistic children.   The cause might be a pollen allergy, food allergy or indeed an illness that does not cause a fever. That last part might sound odd, but fever actually reduces autistic behaviours.   This has been noted and documented by many, but never conclusively explained.   Lots of parents have noticed and one even created a blog about it , but they have not explained it. To investigate the fever effect, you first need to understand thermoregulation, the process by which the body sets and maintains its temperature and the role played by of the HPA axis ( hypothalamic-pituitary-adrenal axis ).   The simplified explanation is that the body initiates a fever as part of its defence mechanism to the threat that has been detected, like an infection of some kind.   Certain hormones are released so as to raise and then maintain a steady higher temperature; they include TR...

Peter Hypothesis Regarding the Cause of Autism

Peter Hypothesis Regarding the Cause of Autism,   The Predisposition of some Children towards it and Implications for Treatment Autism is a spectrum of behaviours and disorders that result from damage and subsequent malformation of the developing cerebellum.   The damage in classic autism occurs in utero, whereas in the case of regressive autism, there is a second oxidative shock that occurs around a key point in brain development, triggering the onset of autism.   The cause of the cerebral damage is an oxidative shock from one or more of a variety of possibilities, not limited to, maternal stress and infection during pregnancy and toxins such as mercury crossing the blood brain barrier (BBB).   Individuals with autism, and many of their close relatives, have a predisposition to the condition, due to an inherited over-reactive immune system. The immune system may have become over-reactive to infection partly due to a lack of the on-going attacks, for which it ha...