PLT Test Blog

Rathaus/City Hall in Hanover, Germany       Attribution:  Thomas Wolf,  www.foto-tw.de The short version of this post is that the old German diuretic Azosemide delivers the same autism benefit as the popular diuretic Bumetanide, but it has a different profile of diuresis.   Azosemide may indeed be more potent at blocking NKCC1 in the brain, but this needs to be investigated/confirmed.   For some people Azosemide will be a better choice than Bumetanide. The bulk of today’s post is really likely to be of interest only to bumetanide users and the French and German bumetanide researchers. I did suggest recently when I published version 5 of Monty’s PolyPill , that it is getting close to the final version.   Some of the potential remaining elements have already been written about in this blog, but I have not finished evaluating them.   Azosemide falls into this category. One theme within this blog has been to increase the “autism effect...

Today’s post is really for the regular readers of this blog who are interested in the GABA switch and Bumetanide. It is not light reading.  We see how advanced some Taiwanese researchers are in their understanding of GABA A dysfunctions in Huntington’s Disease. Taipei 101, briefly the world’s tallest building It is an excellent paper and much of it is applicable to autism. There are some omissions, but you will struggle to find a more complete paper. They even go into the detail of altered the sub-unit expression of GABA A receptors that occurs as the disease progresses. I think that correcting sub-unit miss-expression has great potential in treating some autism. Huntington’s is an inherited brain disorder that first manifests itself around the age of 40 and then progresses for the next 15 to 20 years. Much autism is present prior to birth but there is a progression that occurs as the brain develops in early childhood. Some people do seem to be entirely typical at birth and only...