NMDAR hypo-function causing E/I imbalance in Autism and Schizophrenia – Baclofen, Sodium benzoate and Cinnamon (again)
Click on figure to enlarge Source of text quoted: E-I Balance and Human Diseases – from Molecules to Networking Interpretation, extrapolation and graphic - Peter Today’s post is not the one I intended. It nearly got tucked into long complicated one, that most people might not read. I should caution that I am perhaps over-simplifying something that is extremely complicated, but no one fully understands the subject. There is much talk in autism about the imbalance between excitatory and inhibitory processes. In this blog this is normally all about the inhibitory neurotransmitter, GABA, not functioning properly. There is of course another side to the story. The excitatory neurotransmitter Glutamate signals via receptors including the NMDA receptors. If signaling via these receptors is either up or downregulated, the delicate balance between excitatory and inhibitory can again be lost. What caught my interest was an experiment on mice that caused downregula...