PLT Test Blog

Piperine/Pepper             Resveratrol/Red wine          Sunitinib/Sutent    This post is all about lowering chloride within neurons, by increasing the expression of the transporter that lets it leave, called KCC2. Today’s post is one I never finished writing from last year; I looked up the price of Sutent/Sunitinib and then I remembered why. It does again highlight how cancer drugs, when they become cheap generics, will provide interesting options for autism treatment. It also shows again how Rett Syndrome is getting attention from researchers. It also highlights that really clever Americans are looking for bumetanide alternatives, in the false belief that bumetanide has troubling side effects that cannot be managed/mitigated. The study is by some clever guys in Cambridge Massachusetts. Another group of clever guys from MIT burned through $40 million dollars a few years ago trying to develop R-Baclofen for Fragile-X...

Today’s post is about further refining antioxidant therapy. As we saw in a recent post, oxidative and nitrosative stress is a very common feature of autism and is treatable with OTC products. The cheapest antioxidant, N-acetylcysteine (NAC), looks to be the best one, but there are numerous others with exotic names and equally   exotic prices. Today we just look at selenium and molybdenum.   Selenium was on my to-do list for a long time because it affects some key enzymes call GP X (glutathione peroxodases). Molybdenum was enthusiastically recommended in a recent comment and this blog has previously touched on Molybdenum Cofactor Sulfurase (MOCOS). Rather surprisingly, there is a commercial product that contains NAC, Selenium and Molybdenum.   Selenium and GP X (glutathione peroxodases) There are eight different glutathione peroxodases , but GPx1 , GPx2 , GPx3, and GPx4 are all made from selenium. GP X speeds up the antioxidant reactions that involve glutathione (...