Leptin Signaling and JAK Inhibitors in Early Onset Autism - perhaps RORα and Adiponectin?
A future baldness therapy (a JAK inhibitor) to treat some autism? Today’s rambling post has been pending for some time. It got left on one side, but is interesting and can be applied. As we know there are distinct sub-types of autism and fortunately so does Paul Ashwood at the UC Davis MIND Institute. He often splits his findings into regressive vs early onset autism. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p<.006). When further sub-cl...