PLT Test Blog

Following on the previous posts about Tregs (regulatory T cells) and Short Chained Fatty Acids (SCFAs), today we get to the final steps and some more scientific data. Butyric acid seems to be the best choice of an SCFA, as a possible anti-inflammatory autism therapy. We have a research study that measured Butyric acid and compared the levels in people with and without autism.  It also splits out those with and without any GI issues. We have another study showing that Butyric acid “ attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism. ” This is as relevant as you want to believe. Since Butyric acid is widely used worldwide for animals and in Asia for humans, we have a great deal of data available. The research shows that moderately increasing the level of Butyric acid does do good, but go too far and you lose the benefit. (Farmers do not over feed your chickens) In both humans and animals two different methods are used:- 1. ...

Stockholm in spring Hot on the heels of the last post that showed that regulatory T cells (Tregs) may indeed be a useful target to treat inflammation in autism, today’s post is about the particular short chained fatty acid (SCFA) that I have chosen to treat it. There are seven SCFAs:- Formic acid , Acetic acid , Propionic acid , Butyric acid , Isobutyric acid , Valeric acid , Isovaleric acid . Based on my homework, I have chosen Butyric Acid. Some of my posts do not lead to therapeutic interventions, but the posts on Treg and SCFA are going to lead to some good options, particularly for those with GI problems. As usual with effective interventions, there are multiple possible modes of action.  Since I have introduced epigenetics to this blog, I will also highlight a paper showing the epigenetic effects of Butyric Acid.  My real objective is to increase Tregs , as a means of shifting the balance between the proinflammatory IL-6 and the anti-inflammatory IL-10 . Monty, aged 1...