PLT Test Blog

US-Russia cooperation has long been possible in Space, but not so often in Medicine.  NASA reportedly pays Russia $85 million per astronaut to go the International Space Station (ISS).   The US Space Shuttle program ended in 2011, leaving a Russian Soyuz rocket the only way to the ISS. This post comes ahead of the dietary autism post, awaited by Tanya.  It really is just a brief follow-on from the previous post. I have only just come across Anavex, which does add weight to the first post on sigma-1R.                                                                                                                 Hundreds of millions of dollars are being spent in the US to develop a safe sigma-1R ago...

Today’s post may require even regular readers to refresh their memories and look up the meaning of some words. There really is a lot in this post. I had to read it twice. As is often the case, this post started at the end with the therapy (a trial of Afobazole) and then I just looked at why it might be effective. Activate Chaparones Today's post is all about sigma-1 receptors and the many clever things that happen when they are activated. Even the above diagram showing the effect of Sigma-1R is incomplete! In the mouse study below, the Russian researchers looked at the effect of Afobazole treatment just over a few days; I think other effects might have developed if they had looked at an extended time period. They focus on Sigma1-R receptors modulating NMDA-based neurotransmission, but there seem to many possible further effects within the Endoplasmic Reticulum that relate specifically to autism. These researchers have published other studies using Afobazole, including recently one...